Summary details of discovery and replication stage studies.

ARIC = Atherosclerosis Risk In Communities; BHF-FHS = British Heart Foundation Family Heart Study; CARDIA = Coronary Artery Risk Development in Young Adults; CHS = Cardiovascular Health Study; FOS = Framingham Offspring Study; LOLIPOP = London Life Sciences Prospective Population Cohort; PROCARDIS = Precocious Coronary Artery Disease; PROMIS = Pakistan Risk of Myocardial Infarction Study; EPIC-NL = European Prospective Investigation into Cancer & Nutrition (Netherlands) cohort.*All MONICA-KORA cases are either MI or sudden cardiac death.**V2 contains an additional 132 genes (3,857 SNPs) compared to V1. SNPs on V2 were only analysed in studies that used the V2 array.†Details of studies in the CARDIoGRAM Consortium are presented in Table S6.°The 4 studies in the CARe Consortium contributed data only on prevalent CAD cases at baseline for whom ages were not available.