Common-factor GWAS of circadian rhythm phenotypes (chronotype, L5, M10, sleep midpoint) and downstream TWAS / PWAS / fine-mapping / MR pipeline

This dataset accompanies a multi-omics study of circadian rhythm in UK Biobank. Contents code/ : Seven analysis scripts (R + bash + Python) covering GenomicSEM common-factor GWAS, TWAS-FUSION (GTEx cross-tissue sCCA), PWAS (INTERVAL plasma proteins), FUSION/FOCUS/COLOC integration, SuSIE+FINEMAP fine-mapping (echolocatoR), and Mendelian randomization. data/ma_inputs/ : Per-trait .ma summary statistics for chronotype1, L5_timing, M10, Sleep_midpoint (derived fromJones et al. 2019 BOLT-LMM output). data/gsem_factor/ : The common-factor GWAS produced by GenomicSEM commonfactorGWAS (~6.9M SNPs). README.md : Pipeline documentation, data provenance, and external reference links. Individual-level UK Biobank data are not redistributed; this record contains SNP-level summary statistics and analysis code only.