HMBA Adult Human Brain Atlas

The HMBA Adult Human Basal Ganglia Atlas is a three-dimensional (3D) common coordinate framework (CCF) and reference atlas that defines the spatial organization of the basal ganglia of the adult human brain. This atlas uses the HCP template from the August 2025 release, which is an averaged template from 1071 young adult brains scanned at 3T and coregistered with the MNI152 nonlinear space. This atlas includes annotations for basal ganglia including CaH, CaB, CaT, NACc, NACs, OT, GPe, GPi, VeP, PuR, PuM, PuC, PuCv, SN, VTA and STH. This atlas incorporates a unified ontology developed for cross-species comparisons, the Harmonized Ontology of the Mammalian Brain Atlas (HOMBA) and serves as a reference framework for aligning multimodal datasets, including transcriptomics and connectomics. The resource supports data registration, integration, and interpretation across individuals, laboratories, and species, and is designed to be iteratively refined with new data to capture individual variability and emerging anatomical detail as part of the BRAIN Initiative Cell Atlas Network.

This atlas represents a composite resource consisting of: (1) HCP-Young Adult 2025 coordinate space (custom WU-Minn HCP Consortium Open Access Data Use Terms); (2) annotation set (CC BY 4.0); (3) terminology set (CC BY 4.0). Users must comply with the license terms of each component.

HMBA成人人类基底神经节图谱（HMBA Adult Human Basal Ganglia Atlas）是一款三维（3D）通用坐标框架（common coordinate framework, CCF）及参考图谱，用于定义成人人类大脑基底神经节的空间组织架构。该图谱采用2025年8月发布的HCP模板，该模板是对1071名在3T磁共振扫描仪下成像的青年成人大脑进行平均后得到的模板，并已与MNI152非线性空间完成配准。该图谱涵盖基底神经节的多项解剖注释，包括CaH、CaB、CaT、NACc、NACs、OT、GPe、GPi、VeP、PuR、PuM、PuC、PuCv、SN、VTA与STH。该图谱整合了为跨物种比较开发的统一本体——哺乳动物脑图谱统一本体（Harmonized Ontology of the Mammalian Brain Atlas, HOMBA），可作为对齐转录组学（transcriptomics）与连接组学（connectomics）等多模态数据集的参考框架。本资源支持跨个体、跨实验室及跨物种的数据配准、整合与解读，且作为“脑计划细胞图谱网络（BRAIN Initiative Cell Atlas Network）”的组成部分，旨在通过新增数据进行迭代优化，以捕捉个体差异与新兴解剖学细节。

该图谱属于复合式资源，由以下三部分构成：(1) HCP-青年成人2025坐标空间（需遵循定制的WU-Minn HCP联盟开放获取数据使用条款）；(2) 注释集（采用知识共享署名4.0（CC BY 4.0）协议）；(3) 术语集（采用知识共享署名4.0（CC BY 4.0）协议）。用户必须遵守各组件的许可条款。