Synthesis of 2‑Aryl/Heteroaryloxazolines from Nitriles under Metal- and Catalyst-Free Conditions and Evaluation of Their Antioxidant Activities

The synthesis of structurally diverse
2-aryl/heteroaryloxazolines
from nitriles and aminoalcohols has been achieved under metal- and
catalyst-free conditions in good to excellent yields. An array of
functional groups are well-tolerated, thus, allowing the introduction
of many important biologically active motifs such as azoles, ring-fused
azoles, saturated heterocyclics, and amines in 2-aryloxazoline scaffolds.
An evaluation of the antioxidant properties using the DPPH (diphenyl
picryl hydrazyl) assay method shows the pyrrole-functionalized 2-aryloxazoline
to be the best antioxidant among all the synthesized 2-aryl/heteroaryloxazolines.