Supplementary Material for "Efficacy and Safety of Radiotherapy and Systemic Treatments in Adrenocortical Carcinoma: Systematic Review and Meta-Analysis"

This supplementary material supports a manuscript submitted to The Journal of Clinical Endocrinology & Metabolism, investigating the efficacy of radiotherapy and systemic treatments in the management of adrenocortical carcinoma. The document comprises supplementary tables detailing the PRISMA checklist, baseline characteristics of the included studies, a synthesis of the main findings from the systematic review, and an evaluation of the certainty of evidence according to the GRADE framework. In addition, it contains a comprehensive set of forest plots illustrating the impact of mitotane, radiotherapy, and chemotherapy on oncological outcomes such as overall survival and recurrence-free survival. The supplementary material also presents the results of the risk of bias assessments of the included studies, as well as publication bias analyses, subgroup analyses based on data source, and leave-one-out sensitivity analyses performed to explore potential sources of heterogeneity.