A Co(II)-based coordination polymer: inhibitory activity on cervical cancer cells

By using a mixed-ligand approach, a new Co(II)-bearing coordination polymer (CP) with the chemical formula of [{Co(BINDI)0.5(bpa)0.5(H2O)}·4H2O]n (1, H4BINDI = N,N′-bis(5-isophthalic acid)naphthalenediimide, bpa = 1,2-bis(4-pyridyl)ethane) has been synthesized by room temperature self-assembly and structurally characterized successfully. Furthermore, a process of sonochemistry with oleic acid treatment at 453 K was used to produce the nanostructure 1 (denoted as nano 1 hereafter). The inhibitory effect of nano 1 on cervical cancer cells was determined. Firstly, the CCK-8 assay was performed. The Reverse Transcription Polymerase Chain Reaction (RT-PCR) assay was performed and the relative expression levels of miR-16-1 were determined. Then, the western blotting detection was conducted and the Bcl-2 expression level after nano 1 treatment was evaluated.