SNP Allocation For Estimating Heritability (SAFE-<i>h</i>²): A tool to explore genomic origins of phenotypes for estimation of SNP heritability using additive-only allelic effects or additive and non-additive allelic effects

SAFE-<i>h</i>²is developed under an academic research study to provide proper estimates of SNP heritability. For this, SAFE-<i>h</i>²creates heritability profiles to prevent SNPs with illogical negative contributions to heritability. It also minimizes the contributions by false-positive SNP hits. Finally, SAFE-<i>h</i>² can perform a joint analysis on both additive and non-additive allelic effects. Therefore, it also provides the chance for GWASs to perform linear association tests while capturing both additive and non-additive effects.<br><b>Software Availability:</b> SAFE-<i>h</i>²(SNP Allocation For Estimating Heritability)<b> </b>contains the compiled SAFE-<i>h</i>² scripts with related installation and usage manual<b> (Download link: </b><b>https://github.com/SAFE-h2/SAFE-h2-v2024-1).</b><br>An old version also exists at https://github.com/SAFE-h2/SAFE-h2.Read the related research article “<b>On the Genetic Origins of Phenotypes in Genome-Wide Association Studies: The SNP Allocation For Estimating Heritability (SAFE-</b><b><i>h</i></b>^{<strong>2</strong>}<b>) Tool to Explore Additive-only Allelic Effects or Additive and Non-Additive Allelic Effects</b><b>” (doi:</b> https://doi.org/10.1101/2023.08.28.555092<b>; </b>https://www.biorxiv.org/content/10.1101/2023.08.28.555092v6) for the full study and descriptions.<br><b>Citation: </b><i>Behrooz Darbani, Mogens Nicolaisen. </i>On the Genetic Origins of Phenotypes in Genome-Wide Association Studies: The SNP Allocation For Estimating Heritability (SAFE-<i>h</i>²) Tool to Explore Additive-only Allelic Effects or Additive and Non-Additive Allelic Effects. doi: https://doi.org/10.1101/2023.08.28.555092<b>Contact: [e-mail], [e-mail]</b>