The Dual Role of CREPT in Glioblastoma: Promoting Proliferation and Shaping an Immunosuppressive Microenvironment through Chemo-MO and GZMK⁺ T Cell Interaction

Elevated CREPT promotes tumor cell proliferation and enhances CCL2 secretion, thereby recruiting Chemo-MOs. These Chemo-MOs then engage in regulatory interactions with GZMK+CD8+ T cells, suppressing T cell infiltration and ultimately establishing a robust immunosuppressive microenvironment. RNA-seq profiling of wildtype U87MG cells and their knockdown derivatives(shCREPT)