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An alternative stereoselective total synthesis of (-)-pyrenophorol

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Taylor & Francis Group2019-08-06 更新2026-04-16 收录
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资源简介:
The total synthesis of 16-membered C<sub>2</sub>–Symmetric dilactone (-)-Pyrenophorol was accomplished starting from commercially available (<i>S</i>)<i>-</i>epoxide prepared by hydrolytic kinetic resolution of (±) – epoxide with key steps of Grignard reaction, Swern oxidation, Wittig reaction and cyclization was achieved by intermolecular Mitsunobu cyclization. The synthesis of (-)-Pyrenophorol accomplished from cheaply available starting material, easily work-up procedures and reduction of cost in industrial process were major advantages of this route.
提供机构:
Rudraraju Ramesh Raju; Choragudi Chandrasekhar; Gurrala Alluraiah; Reddymasu Sreenivasulu
创建时间:
2019-04-11
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