Transcriptome comparison of C. glutamicum wild type (wt) and the ΔcopRS deletion mutant after cultivation in CGXII minimal medium supplemented with 21.25 µM CuSO4 (Cu↑) using DNA microarrays.

The mRNA ratios shown represent mean values from five independent DNA microarray experiments starting from independent cultures. The strains were cultivated in CGXII minimal medium with 4% (w/v) glucose with additional 20 µM CuSO4 and mRNA was prepared from cells in the exponential growth phase. The table includes those genes which showed an at least threefold changed mRNA level (increased or decreased) in at least three of the five replicates with a P-value of ≤0.05. The putative promoter regions of the genes indicated with a † were chosen for the EMSAs (see Fig. S1).