A Multicenter Randomized Controlled Trial Designed to Evaluate Follow-up Surveillance Strategies for Colorectal Cancer: The Japan Polyp Study

Interventions: 1, 3 year follow-up after two complete colonoscopies with the removal of all polyps detected 3 year follow-up after two complete colonoscopies with the removal of all polyps detected Primary outcome(s): The primary goal is to address the hypothesis that after two complete colonoscopies with the removal of all polyps detected, the incidence of clinically significant lesions would not be different between patients undergoing two further follow-up examinations and those undergoing just one. Clinically significant lesions are defined as index lesions (IL): if they are larger than 10mm; if they have high-grade dysplasia; or if they are invasive. Study Design: Parallel Randomized