Structure of RORgt in complex with a novel inverse agonist.
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Structure of RORgt in complex with a novel inverse agonist. Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 5-[(5R)-5-[(7-fluoro-1,1-dimethyl-2,3-dihydro-1H-inden-5-yl)carbamoyl]-2-methoxy-7,8-dihydro-1,6-naphthyridin-6(5H)-yl]-5-oxopentanoic acid, Nuclear receptor ROR-gamma, ... Authors: Skene, R.J, Hoffman, I. Deposit date: 2018-07-13 Release date: 2019-07-17 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.47 Å) Cite: Design, Synthesis, and Biological Evaluation of Retinoic Acid-Related Orphan Receptor gamma t (ROR gamma t) Agonist Structure-Based Functionality Switching Approach from In House ROR gamma t Inverse Agonist to ROR gamma t Agonist. J.Med.Chem., 62, 2019
创建时间：
2018-07-13
