Deciphering variable resistance to novel carbapenem-based beta-lactamase-inhibitor combinations and transmission pathways in a multiclonal outbreak by KPC carbapenemase-producing Klebsiella pneumoniae resistant to ceftazidime/avibactam

Characterization of an outbreak caused by KPC-producing K. pneumoniae resistant to ceftazidime/avibactam with variable resistance also to carbapenem-based beta-lactamase-inhibitor combinations, by exploring the underlying resistance mechanisms and transmission dynamics.