Wfs1^em1Ptsn

This allele was created in embryos from Sprague-Dawley rats (Crl: CD(SD). A 27 amino acid deletion in exon 5 (aa212-238) was identified.<br>ASSOCIATED WITH abnormal brainstem morphology; decreased insulin secretion; decreased pancreatic beta cell mass; ASSOCIATED WITH cataract; diabetes mellitus; glucose intolerance

此等位基因由 Sprague-Dawley 大鼠（Crl: CD(SD)）的胚胎中构建而成。在第5外显子（氨基酸212-238位置）处检测到一个27个氨基酸的缺失。该突变与脑干形态异常、胰岛素分泌减少、胰腺β细胞质量降低相关，并伴有白内障、糖尿病及葡萄糖耐受性降低等症状。