Stereoselective Synthesis of Fluorinated 2,3-Dihydroquinolin-4(1<i>H</i>)-ones via a One-Pot Multistep Transformation
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A new organocatalytic one-pot multistep transformation via Knoevenagel condensation/aza-Michael addition/electrophilic fluorination has been developed. Simple starting materials were used under mild conditions to construct fluorinated 2,3-dihydroquinolin-4(1H)-one derivatives in good to high yields (up to 98%) and diastereoselectivities (dr up to 99/1).
创建时间:
2016-02-22



