Mutant RAS:p-RAF complexes phosphorylate MAP2Ks
收藏reactome.org2025-01-21 收录
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MAP2K proteins are phosphorylated downstream of oncogenic RAS mutants; somewhat surprisingly, however, steady state levels of phospho-MAP2K and phospho-MAPKs are not always elevated in cancer cells (reviewed in Ramos, 2008; Neuzillet et al, 2014; Stephen et al, 2014).
MAP2K蛋白在致癌RAS突变下游发生磷酸化;然而,出人意料的是,磷酸化MAP2K和MAPKs的稳态水平在癌细胞中并不总是升高(参见Ramos,2008年;Neuzillet等,2014年;Stephen等,2014年的综述)。
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