A Pilot Study Randomized Trial of Intravenous Gammaglobulin Therapy for Patients With Neuroblastoma Associated Opsoclonus-Myoclonus-Ataxia Syndrome Treated With Chemotherapy and Prednisone

This randomized phase III trial is studying cyclophosphamide, prednisone, and immunoglobulin
to see how well they work compared to cyclophosphamide and prednisone alone in treating
patients with abnormal eye and trunk muscle movements (known as opsoclonus myoclonus ataxia)
associated with neuroblastoma. Drugs used in chemotherapy work in different ways to stop
tumor cells from dividing so they stop growing or die. Steroid therapy decreases
inflammation. Combining chemotherapy and steroid therapy with immunoglobulin may be effective
in treating abnormal muscle movement associated with neuroblastoma.
Chemotherapy(cyclophosphamide), prednisone and intravenous gamma globulin all suppress the
immune system which may be helpful in treating opsoclonus-myoclonus-ataxia (OMA).