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PPIA-mediated stabilization of GAU1-SENP5 triplex activates the oncogene SENP5 drives tumorigenesis

NIAID Data Ecosystem2026-05-02 收录

非编码RNA三链体调控

肿瘤发生机制

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE247292 数据链接链接失效反馈

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资源简介：

All DNA interacting with GAU1 lncRNA were detected by triplex The DNA interacting with GAU1 were pulled down by triplex assay.

应用场景：

创建时间：

2024-11-04

肿瘤发生机制

细胞衰老调控

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p53 amyloid formation induced cellular transformation and tumor formation in xenograft model

p53

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p53 mutation and its subsequent loss of function along with gain of oncogenic functions is associated with cancer. However, the exact mechanism of how altered p53 acts as an oncogene is not clear yet.

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Identification of a novel TINCR-EGFR signaling pathway loop which initiates receptor tyrosine kinases cascade and confers tumorigenesis in human cancer

癌症信号通路

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RNA sequencing was performed to investigate the potential crosstalk between TINCR and microRNAs. Overall design: microRNA profiles of T47D with TINCR knockdown and scramble were generated by deep sequ

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NGS-mRNA in lung tissues in RAG1-/- and in RAG1-/- Sgo1-/+ mice

基因表达分析

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We compared lung mRNA expression profiles between RAG1-/- control and RAG1-/- Sgo1-/+ chromosome instability model mice. RAG1-/-Sgo1-/+ mice developed significantly more spontaneous lung tumors. Char

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YAP1 and PRDM14 converge to regulate cell survival and tumorigenesis

肿瘤发生机制

疾病靶点发现

The transcriptional co-activator YAP1 oncogene is the downstream effector of the Hippo pathway, which regulates tissue homeostasis, organ size, regeneration and tumorigenesis. Multiple cancers are dep

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PPIA-mediated stabilization of GAU1-SENP5 triplex activates the oncogene SENP5 drives tumorigenesis

资源简介：

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