Demographic and clinical characteristics of HCs, CIS patients, all MS patients and MS subtypes patients.

Data are expressed as median and range (in brackets). There were no statistically significant differences between HCs and MS patients in age (p = 0.721; 0.153) or sex (p = 0.148; 0.332). § Mann-Whitney U test between CIS and MS patients. * Kruskal Wallis one-way analysis of variance among MS patients. HCs = healthy controls subjects; CIS = clinically isolated syndrome; MS = multiple sclerosis; MS Subtypes: RR = relapse remitting; SP = secondary progressive, PP = primary progressive.