Exploring enamel microstructure in teeth affected by Molar Incisor Hypomineralisation (MIH) using synchrotron propagation phase contrast mic

Molar-Incisor Hypomineralisation (MIH) is a major public health issue involving enamel defects in the developing permanent teeth of children (high prevalence: 15%). MIH defects are characterised by a reduced mineral density and a localised discoloration of enamel, and a loss in chewing efficiency. This complicates treatment and results in a substantial cost for the health system. Despite several hypotheses, aetiological factors remain unknown. We aim to visualize the fine enamel microstructure and quantify the timing and pattern of stress events recorded in MIH teeth. Only phase contrast synchrotron micro-CT at ID19 enables high energy low dose imaging with a large field of view of tooth microstructure. Exploring past populations affected by MIH would enable documenting natural aetiological factors, and downplaying putative causative factors related to the modern lifestyle (e.g., drugs, environmental pollutants). This work should result in improving the treatment of MIH in patients.