TAF7 Directly Targets SAA1 to Enhance Triple-Negative Breast Cancer Metastasis via Phosphorylating E-Cadherin and N-Cadherin

we analyzed the transcriptome profiles of 13020 cells from the TNBC sample. Our data unveiled an aggressive group of epithelial cells, potentially metastatic and resistant to chemotherapy. Subsequently, we demonstrated that the transcription factor TAF7 promotes tumor progression by directly binding the promoter region of SAA1, enhancing the transcriptional activity of SAA1, and SAA1 protein expressed by tumor cells further promoted the invasion and metastasis of TNBC by inducing the phosphorylation of E-cadherin and N-cadherin. These results offer crucial experimental evidence for the diagnosis and treatment of TNBC, suggesting that TAF7 can serve as a novel therapeutic target for human TNBC.