Biomarkers Identifying Tendency to Suicide: Detection of Biomarkers in Adolescents presenting Suicidal Ideation or Suicidal Behaviour for Early Prevention and Intervention

Introduction This database includes the raw data linked with the paper “Biomarkers Identifying Tendency to Suicide: Detection of Biomarkers in Adolescents presenting Suicidal Ideation or Suicidal Behaviour for Early Prevention and Intervention“. In this paper, we report on the clinical, sociodemographic, and inflammatory biomarker profiles of adolescents, categorized into three groups: No Suicidal Concern (NSC), Suicidal Ideation only (SI), and Suicidal Behaviours (SB). The aims are to (1) characterize these profiles across groups, (2) investigate group differences in concentrations of biomarkers (TNF-α, IL1-β, IL-6, S100B, NFL), and (3) examine correlations between biomarker levels and suicidal ideation/behaviours. Methods Data include clinical interviews, sociodemographic and psychosocial variables, validated psychiatric assessment scales (C-SSRS, CGAS, CGI), and serum concentrations of inflammatory biomarkers (TNF-α, IL1-β, IL-6, S100B, NFL) measured via immunoassay. Biological and clinical data were collected from a cross-sectional sample of 106 adolescents aged 12–18 years, admitted to a neuropsychiatry unit. Participants were categorized into clinical groups based on recent suicidal ideation and behaviour using the C-SSRS scale. Results Among 106 adolescents (79% female, Mage = 15.4 years), the groups did not differ significantly in age, sex, or most sociodemographic variables. The Kruskal–Wallis test found a significant difference in NFL biomarker levels across groups (higher in SB than SI). Other biomarkers did not differ significantly by group. Correlations showed NFL was positively associated with suicide attempt history, and S100B and IL1-β showed small-to-moderate associations with sex at birth and age, respectively.