Expression data from Sprague Dawley rat lenses cultured for 4 days - addition of various inhibitors. Expression data from Sprague Dawley rat lenses cultured for 4 days - addition of various inhibitors

We created a rat sugar cataract model and examined the effects of various inhibitors on lens clouding. Lenses were removed from 6-week-old SD rats and cultured in M199 medium containing 30 mM galactose. Overall design: All lens samples were compared to galactose. First, we extracted a group of genes significantly reduced in the Ctrl and C646, and a group of genes significantly. increased in the TSA. Next we compared genes that had more than doubled variation in any of the non-TSA samples