Cancer stem cells (CSCs) are attractive targets for cancer therapy, however, little is known about how to target CSCs without affecting the normal stem cell population. Here we report the ribosome-pro

NIAID Data Ecosystem70

Arginine starvation elicits chromatin leakage and cGAS-STING activation via epigenetic silencing of metabolic and DNA-repair genes [ChIP-seq]

癌症代谢治疗

表观遗传调控

One of the most common metabolic defects of cancer cells is the deficiency in arginine synthesis due to suppressed expression of argininosuccinate synthetase 1 (ASS1) which renders cancer cells auxotr

NIAID Data Ecosystem40

Protein synthesis inhibitors stimulate MondoA transcriptional activity by driving accumulation of glucose 6-phosphate

癌症代谢治疗

转录调控机制

BACKGROUND: Protein synthesis is regulated by the availability of amino acids, the engagement of growth factor signaling pathways and ATP levels sufficient to support translation. Crosstalk between th

NIAID Data Ecosystem70

Inhibiting MYC-regulated Glutaminase Metabolic Axis is an Effective Synthetic Lethal Approach for Treating Chemoresistant Cancers. Inhibiting MYC-regulated Glutaminase Metabolic Axis is an Effective Synthetic Lethal Approach for Treating Chemoresistant Cancers

癌症代谢治疗

合成致死治疗

Amplification and expression of the MYC oncogene in tumor cells, including ovarian cancer cells correlates with poor responses to chemotherapy. As MYC is not directly targetable, we have analyzed mole

NIAID Data Ecosystem50

Comprehensive analysis of glycolytic enzymes as therapeutic targets in the treatment of Glioblastoma

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