Electrochemical Bisarylation of Carbonyls: A Direct Synthetic Strategy for Bis(indolyl)methane

An interesting electrochemical direct bisarylation of
carbonyls
with indole derivatives to afford the corresponding bis(indolyl)methane
(BIM) derivatives is described. The developed protocol is suitable
for aliphatic, aromatic, and heteroaromatic aldehydes, which react
with various electron-rich and electron-poor indoles to afford the
corresponding BIMs in good to excellent yields. Isatin derivatives
also underwent bisarylation with various indole derivatives under
the influence of current to afford the corresponding BIMs in excellent
yields.