Cell atlas of mouse colon tissues of liver cirrhosis mouse

Liver disease alters the gut microenvironment by liver-gut axis. To investigate the composition and transcriptome changes of various intestinal cell populations in liver cirrhosis, we delineated a single-cell atlas of the colon from mice treated CCl4 for 6 weeks. Overall design: 6-week-old SPF mice were treated with CCl4 for 6 weeks, and the mild-colon tissues were harvested for single-cell RNA sequencing.