Dataset: Polymeric Implant to Assess the Neurotoxicity of Subacute Exposure to 2,2',5,5'-Tetrachlorobiphenyl-4-ol in Male Rats

This dataset summarized a study of investigating the subacute neurotoxicity of a human-relevant metabolite, 2,2',5,5'-tetrachlorobiphenyl-4-ol (4-52), on male adolescent Sprague Dawley rats, via a novel polymeric implant drug delivery system grafted subcutaneously, at total loading concentrations ranging from 0, 1, 5, and 10% of the implant (w/w) for 28 days. 4-52 and other possible hydroxylated metabolites in serum and vital tissues were quantified using gas chromatography with tandem mass spectrometry (GC-MS/MS). The dataset contains 4-52 concentration in mass (ug) and percentage (%) in medium from in vitro release experiment, mass (ng) and concentration (ng/g tissue) of 4-52 and its metabolites in serum, lung, brain and liver, the body weight and tissue weight, the neurobehavioral testing data, the histopathology evaluation and images, and the QA/QC data.