Induced pluripotent stem cells were gene edited to introduce heterozygous (promoter deletion, start site deletion, and exon 27 frameshift) and homozygous (exon 27 frameshift) mutations. iPSCs were dif

NIAID Data Ecosystem40

Transcriptome study of MYBPC3 loss of function mutations

心肌病基因机制

转录组分析

Induced pluripotent stem cells were gene edited to introduce heterozygous (promoter deletion, start site deletion, and exon 27 frameshift) and homozygous (exon 27 frameshift) mutations. iPSCs were di

NIAID Data Ecosystem10

Expression of foetal gene Pontin is essential in protecting heart against pathological remodelling and cardiomyopathy

心脏病理重构

Hippo信号通路

Cardiac remodelling is a key process in the development of heart failure. Reactivation of foetal cardiac genes is often associated with cardiac remodelling. Here we study the role of Pontin (Ruvbl1),

NIAID Data Ecosystem00

Expression of foetal gene Pontin is essential in protecting heart against pathological remodelling and cardiomyopathy

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