Electrochemical Trifluoromethylation of Glycals
收藏NIAID Data Ecosystem2026-03-12 收录
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https://figshare.com/articles/dataset/Electrochemical_Trifluoromethylation_of_Glycals/16451431
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资源简介：
Carbohydrates
play essential roles in various physiological and
pathological processes. Trifluoromethylated compounds have wide applications
in the field of medicinal chemistry. Herein, we report a practical
and efficient trifluoromethylation of glycals by an electrochemical
approach using CF3SO2Na as the trifluoromethyl
source and MnBr2 as the redox mediator. A variety of trifluoromethylated
glycals bearing different protective groups are obtained in 60–90%
yields with high regioselectivity. The successful capture of a CF3 radical indicates that a radical mechanism is involved in
this reaction.
创建时间：
2021-08-26
