Gene expression data from iPSC-derived astrocytes, comparison. Homo sapiens

Alexander disease (AxD) is a fatal neurological illness characterized by white-matter degeneration and formation of Rosenthal fibers, which contain glial fibrillary acidic protein (GFAP) as astrocytic inclusion. AxD is mainly caused by a gene mutation encoding GFAP, although the underlying pathomechanism remains unclear. Overall design: We differentiated human iPSCs into astrocytes and analyzed gene expression profiles of control and the AxD astrocytes. Comparison between control (n=3) and AxD (n=1)