Single cell sequencing of identified Drosophila sensory neurons

The neural circuitry underlying innate behaviors must be pre-specified using precise molecular instructions. However, it is not clear what specific molecules are required to generate one neuron's wiring pattern that make it distinct from a neighboring neuron's wiring pattern. Here, we repeatedly sequenced three identified Drosophila sensory neurons that each have a unique and stereotyped hard-wired synaptic connectivity, to determine the cell surface molecules that distinguish their identities.