Integrated transcriptomics network analysis of miRNA and mRNA in human myometrium in term and preterm labor.. Homo sapiens

Myometrial biopsies were collected from 20 women undergoing primary cesarean sections in well-characterized clinical scenarios: 1) term labor of spontaneous onset (TL, n=5); 2) term non-labor (TNL, n=5); 3) spontaneous PTB in the setting of chorioamnionitis (PTB-HCA) and 4) indicated preterm birth (PTB) non-labor (PTB-NL, n=5). RNAs were profiled using 2nd-generation RNA sequencing. Overall design: We applied integrated RNA-sequencing of long RNAs and miRNAs along with various computational algorithms to uncover novel molecular signals that could be responsible for the transition of the human myometrium from a quiescent to the contractile laboring state Raw data for this series are not available because consent forms do not allow for public access to raw data.