Generation of mature compact ventricular cardiomyocytes from human pluripotent stem cells. Generation of mature compact ventricular cardiomyocytes from human pluripotent stem cells

Here we established a differentiation strategy that promotes the specification, proliferation and maturation of a compact cardiomyocyte population from hPSCs. The cardiomyocytes generated under these conditions display the hallmark phenotypic characteristics of post-natal cardiomyocytes. Overall design: Examination of heterogeneity and global transcriptome between immature and mature VCMs