Poultry by-products as source of collagen, nanokeratin and bioapatite for biomedical use

ABSTRACT Xenogeneic sources are attractive for the development of natural and sustainable biomaterials. The objective of this study was to extract and perform the physicochemical and biological characterization of poultry collagen (G1), nanokeratin (G2) and bioapatite (G3). The test materials were analyzed through SEM, FTIR, TGA, EDS and DRX. The in vivo biocompatibility and biodegradation of the materials were analyzed histopathologically in mice at 1, 3 and 9 weeks post-subcutaneous grafting compared to positive (collagen or commercial bone) and negative (no graft) controls. The obtained data was submitted to intergroup statistical analysis using the ANOVA method with the Tukey-Kramer post-hoc test, and differences were considered significant for p