Delineating mechanisms of immune evasion in lung carcinoma in situ

Background: Lung carcinoma-in-situ (CIS) lesions are the pre-invasive precursor to lung squamous cell carcinoma. However, only half progress to invasive cancer in three years, while a third spontaneously regress. Molecular profiling techniques have identified marked differences between progressive and regressive lesions. Here we present laser-captured stromal tissue, adjacent to previously profiled CIS lesions, to examine the role of the tumour microenvironment in spontaneous lesion regression. All samples in this dataset are paired with matched CIS lesions in dataset GSE108082. Progressive and regressive lung CIS lesions were laser-captured and their transcriptome interrogated. This data set represents matched laser-captured stromal tissue adjacent to previously profiled CIS lesions (GSE108082). Differential expression analysis was performed to identify stromal differences between progressive and regressive lesions.