BindingDB Entry 50043546: Discovery of NMS-E973 as novel, selective and potent inhibitor of heat shock protein 90 (Hsp90).

Small molecule binding data for protein AKT/p21CIP1, ALK tyrosine kinase receptor, Aurora kinase B/Inner centromere protein, CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase), Casein kinase II alpha/beta, Dual specificity protein kinase TTK, Focal adhesion kinase 1/vascular endothelial growth factor receptor 3, Hepatocyte growth factor receptor, Inhibitor of NF-kappa-B kinase (IKK), Insulin receptor, Insulin-like growth factor I receptor, JAK3/JAK1, Kinesin-1 heavy chain/ Tyrosine-protein kinase receptor RET, MAP kinase ERK2, MAP kinase-activated protein kinase 2, Maternal embryonic leucine zipper kinase (MELK), Neurotrophic tyrosine kinase receptor, Pancreatic endoplasmic reticulum kinase (PERK), Platelet-derived growth factor receptor beta, Serine/threonine-protein kinase Aurora, Serine/threonine-protein kinase Chk1, Serine/threonine-protein kinase EEF2K, Serine/threonine-protein kinase MST4, Serine/threonine-protein kinase NEK6, Serine/threonine-protein kinase PAK 4, Serine/threonine-protein kinase PIM, Serine/threonine-protein kinase PLK1, Serine/threonine-protein kinase haspin, Tyrosine kinase non-receptor protein 2, Tyrosine-protein kinase BRK, Tyrosine-protein kinase JAK1, Tyrosine-protein kinase JAK2, Tyrosine-protein kinase SYK, Tyrosine-protein kinase ZAP-70, Tyrosine-protein kinase receptor FLT3, and heat shock 70kDa protein 8 isoform 1, Uniprot O00311, O00418, O14757, O14920, O14965, O60674, O96013, P04629, P06213, P07949, P08069, P08581, P09619, P11142, P11309, P23458, P28482, P31749, P33981, P36888, P43403, P43405, P49137, P52333, P53350, P67874, P68400, Q05397, Q07912, Q13882, Q14680, Q8TF76, Q96GD4, Q9HC98, Q9NZJ5, Q9P1W9, Q9P289, and Q9UM73