1

<b>Copyright information:</b>Taken from "GOtcha: a new method for prediction of protein function assessed by the annotation of seven genomes"BMC Bioinformatics 2004;5():178-178.Published online 18 Nov 2004PMCID:PMC535938.Copyright © 2004 Martin et al; licensee BioMed Central Ltd. A query sequence is subjected to a database search. The search results are processed to give a list of pairwise matches with associated R-scores. 2. The R-score for the pairwise match is added to the total score for each GO term associated with that match sequence. 3. The C-score is calculated as the natural logarithm of the total score at the root node. The I-score for each node is calculated as the ratio of the total node score to the root node.