Cryo-EM structure of human organic solute transporter Ost-alpha/beta bound with TLCA

Cryo-EM structure of human organic solute transporter Ost-alpha/beta bound with TLCA Descriptor: (7E,21R,24S)-27-amino-24-hydroxy-18,24-dioxo-19,23,25-trioxa-24lambda~5~-phosphaheptacos-7-en-21-yl (9Z,12E)-octadeca-9,12-dienoate, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Yang, X, Xu, E. Deposit date: 2025-04-24 Release date: 2025-12-10 Last modified: 2026-03-18 Method: ELECTRON MICROSCOPY (3.12 Å) Cite: Structures of Ost alpha / beta reveal a unique fold and bile acid transport mechanism. Nature, 651, 2026