Targeting SWI/SNF ATPases in enhancer-addicted prostate cancer [HiChIP-Seq]
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE171591
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资源简介：
This study profiles chromatin accessibility, gene expresison, transcription factor binding, and three-dimensional DNA-DNA contact changes upon rapid SWI/SNF ATPase inactivation in prostate cancer cells. SWI/SNF ATPases activity was disabled using a novel PROTAC degrader compound targeting the SMARCA2, SMARCA4 and PBRM1 subunits of the SWI/SNF remodeling complex. Distinct prostate cancer cells were treated in vitro with the SMARCA2/4 degrader (AU-15330, abbreviated as AU) for indicated durations (ranging from 4 to 24h) and dosages (ranging from 0.1 - 1uM), and processed for multi-omic characterization.
创建时间：
2022-02-08
