Single−cell RNA-seq reveals cell type-specific molecular and genetic associations with primary open-angle glaucoma

Single-cell RNA sequencing data from peripheral blood PBMC samples for primary open-angle glaucoma (POAG) study This dataset contains processed single-cell RNA sequencing data from 218 samples (POAG cases and controls) using 10X Genomics technology. The data supports the research published in "Single-cell RNA-seq reveals cell type-specific molecular and genetic associations with primary open-angle glaucoma" (accepted for publication in Signal Transduction and Targeted Therapy, STTT). Dataset Contents:Individual sample files: 218 clean h5ad files (one per sample) containing processed single-cell expression matricesSample metadata: Complete sample information including case/control status, demographic data, and clinical characteristicsData format: Standardized h5ad format compatible with scanpy, Seurat, and other single-cell analysis toolsQuality control: Pre-processed data with cell filtering, gene filtering, and basic quality metrics applied Technical Details:Sample type: Peripheral blood mononuclear cells (PBMC)Sequencing technology: 10X Genomics single-cell RNA sequencingSample size: 218 samples (POAG cases and controls)File format: h5ad (AnnData format)Processing: Clean, filtered, and normalized single-cell expression data Usage:This dataset is suitable for single-cell analysis including cell type identification, differential expression analysis, trajectory analysis, and integration with genetic data for POAG research. The data can be directly loaded into popular single-cell analysis frameworks such as scanpy, Seurat, or Scanpy. Related Publication:"Single-cell RNA-seq reveals cell type-specific molecular and genetic associations with primary open-angle glaucoma (accepted for publication in Signal Transduction and Targeted Therapy)