Additional file 2 of Effect of aging on the formation and growth of colonic epithelial organoids by changes in cell cycle arrest through TGF-β-Smad3 signaling
The tumor suppressor Smad4, a key mediator of the TGF-?/BMP pathways, is essential for development and tissue homeostasis. Phosphorylation of Smad4 in its linker region catalyzed by the mitogen-activa
Galunisertib (LY2157299), a selective ATP-mimetic inhibitor of TGF-β receptor I (TGF-βRI), is the only known TGF-β pathway inhibitor. In the present study, we investigated the effect of galunisertib o
We performed RNA-seq to examine the differentially expressed genes (DEGs) in human HCC cell line Huh-7 with or without knock down of MAP3K9-DT/LincNMR upon TGFb stimulation
Transforming growth factor-Ã (TGF-Ã) comprises a key component in the tumor microenvironment. It is reported that TGF-Ã can be pro-tumorigenic or anti-tumorigenic depending on various contexts. Som
In this study we analyzed how multiple enhancers arrange in the 3D-space to control the activation of a specific promoter. Specifically, we did a 4C-seq experiment on a ~374 Kb locus where enhancers a