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Human p38alpha MAP Kinase in Complex with Dibenzosuberone Compound 2

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Protein Data Bank Japan2024-01-17 更新2026-03-21 收录
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Human p38alpha MAP Kinase in Complex with Dibenzosuberone Compound 2 Descriptor: Mitogen-activated protein kinase 14, ~{N}-[2,4-bis(fluoranyl)-5-[[9-(2-morpholin-4-ylethylcarbamoyl)-11-oxidanylidene-5,6-dihydrodibenzo[1,2-~{d}:1',2'-~{f}][7]annulen-3-yl]amino]phenyl]thiophene-2-carboxamide Authors: Buehrmann, M, Rauh, D. Deposit date: 2016-09-12 Release date: 2017-04-19 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.44 Å) Cite: Optimized Target Residence Time: Type I1/2 Inhibitors for p38 alpha MAP Kinase with Improved Binding Kinetics through Direct Interaction with the R-Spine. Angew. Chem. Int. Ed. Engl., 56, 2017
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2016-09-12
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