The memory CD8+ T-cell response in mice is not influenced by time since previous infection

We studied in a mouse model whether priming with IAV at different moments during life affects the T-cell response after a heterosubtypic IAV booster infection at older age. Before the booster infection (at 12 months of age), 6 months-primed mice displayed lower IAV-specific CD8+ T-cell repertoire diversity in the spleen than 9 months-primed mice. Nevertheless, we observed comparable T-cell repertoire diversity before and after the booster infection. These data suggest that the IAV-specific T-cell repertoire after boosting is not influenced by the time post priming.