Comparing sequencing of four proto-typical Burkitt lymphomas (BL) with IG-MYC translocation.
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https://www.omicsdi.org/dataset/ega/EGAS00001000271
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资源简介：
By whole-genome, exome, transcriptome and methylome sequencing of four proto-typical Burkitt lymphomas (BL) with IG-MYC translocation we identified seven recurrently mutated genes including ID3. In an extended cohort, 36/53 (68%) molecularly-defined BL carried potentially damaging mutations of ID3 which were enriched at somatic hypermutation motifs. Only 6/47 (13%) other IG-MYC-positive B-cell lymphomas carried ID3 mutations suggesting cooperation of ID3 inactivation and IG-MYC translocation to be a hallmark of Burkitt lymphomagenesis.EGA study EGAS00001000271
创建时间：
2017-07-26
