Transcriptomic Signature-Guided Depletion of Intermediate Alveolar Epithelial Cells Ameliorates Pulmonary Fibrosis in Mice
收藏NIAID Data Ecosystem2026-05-10 收录
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In this study, we leverage unique transcriptomic signatures identified via scRNA-seq to guide gene delivery to specific cell populations in mouse lungs. We show that targeted depletion of transitional AT2 cells, utilizing diphtheria toxin receptor (DTR)-mediated cell ablation guided by Sprr1a mRNA, ameliorated pulmonary fibrosis in mice.
创建时间：
2026-02-14
