Nucleoprotein is ADP-ribosylated

This COVID-19 event has been created by a combination of computational inference (see https://reactome.org/documentation/inferred-events) from SARS-CoV-1 data and manual curation, as described in the summation for the overall SARS-CoV-2 infection pathway.<br><br>Nucleoprotein (N) is ADP-ribosylated. The modification is maintained both in the cell and in virions (Grunewald et al, 2018). Members of the protein mono-ADP-ribosyltransferase (PARP) enzyme family are thought to catalyze this reaction (Fehr et al. 2020)

本次COVID-19事件系基于SARS-CoV-1数据通过计算推理（详见https://reactome.org/documentation/inferred-events）与人工编纂相结合而成，具体编纂过程详述于SARS-CoV-2感染途径的整体概述中。<br><br>核蛋白（N）发生ADP-核糖基化修饰，此修饰在细胞内和病毒颗粒中均得以维持（Grunewald等人，2018年）。蛋白质单ADP-核糖基转移酶（PARP）酶家族成员被认为催化此反应（Fehr等人，2020年）。