Use of CRISPR/Cas9 with homology-directed repair to silence the human Topoisomerase IIa intron-19 5' splice site: Generation of etoposide resistance in human leukemia K562 cells
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https://www.ncbi.nlm.nih.gov/sra/SRP370666
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资源简介：
Results support the important role of both TOP2a/170 and TOP2a/90 as determinants of sensitivity/resistance to TOP2a-targeting agents. Overall design: CRISPR/Cas9 with homology-directed repair was utilized silencing of the exon 19/intron 19 5' splice site in parental K562 cells.
创建时间：
2022-06-02
