Total Synthesis of (+)-18-epi-Latrunculol A
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https://figshare.com/articles/dataset/Total_Synthesis_of_18_i_epi_i_Latrunculol_A/2380249
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An enantioselective total synthesis of the cytotoxic latrunculin congener (+)-18-epi-latrunculol A has been achieved. Key steps in the synthetic route include an acid-mediated enone cyclization/equilibration sequence, a Carreira alkynylation, and a late-stage Mitsunobu macrolactonization to construct the macrolide skeleton.
创建时间:
2016-02-18



