官方服务:
资源简介:
This data sets are manuscript of the cell metabolim.
应用场景:
相关数据集
SerpinA3N缺失造成小鼠海马刺伤后的学习和记忆损伤
创伤性脑损伤是全球致残和死亡的主要原因,它使患者患痴呆症的风险很高。早期干预被认为是减少可能加重症状的脑损伤发展的关键。在此,我们报道了丝氨酸蛋白酶抑制剂SerpinA3N在海马刺伤(HSI)早期在海马神经元中上调,而其缺乏导致HSI后小鼠更大程度的神经元凋亡和更严重的空间学习和记忆障碍。我们进一步发现MMP2是SerpinA3N的一个关键底物,MMP2特异性抑制剂(ARP100)可以保护HSI后
干细胞与再生医学数据中心2023-04-28 更新200
'构建基因编辑工具鼠,并用已知功能的致死基因验证体内基因敲除的有效性'的相关数据集
CRISPR-stop技术将蛋白质编码序列转化为终止密码子,从而在适当的位置产生了无效等位基因。CRISPR-stop在单细胞期合子中诱导产生Founder 0(F0)纯合突变体小鼠,这避免了小鼠繁殖并可作为非致命基因的快速筛选方法。然而哺乳动物25%的基因,其功能丧失会导致早期死亡。在这里,我们在二细胞期合子中的一个细胞进行CRISPR-stop操作,一种我们称之为嵌合型CRISPR-stop的
中国科学院脑科学数据中心2023-12-11 更新140
Biomarker Benchmark - GSE31048
[NOTICE: This data set has been deprecated. Please see our new version of the data (and additional data sets) here: https://osf.io/mhk93 ] "Wnt pathway is dysregulated in CLL-
DataCite Commons2020-09-04 更新90
Additional file 4: of Stress alters the expression of cancer-related genes in the prostate
Statistical evaluation of metastasis gene expression by ANOVA with Bonferroni post-hoc analysis to determine overall effects of our treatment paradigm. For genes in which a significant main effect (F-
Mendeley Data2024-06-27 更新170
Additional file 17 of A positive feedback loop between PFKP and c-Myc drives head and neck squamous cell carcinoma progression
Supplementary Material 17: Supplementary Table 7. Enciched GO Pathway of differentially expressed genes (shPFKP LIU-LSC-1 cells vs. shSc LIU-LSC-1).
DataCite Commons2024-08-18 更新100



