Cleaned dataset for PubChem AID 743063: qHTS assay of androgen receptor antagonists

This dataset is derived from PubChem BioAssay AID 743063, titled "qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway". The original assay is part of the Tox21 program and evaluates inhibition of androgen receptor (AR) signaling using a beta-lactamase reporter assay in HEK293 cells. Original dataset statistics: - Tested compounds: 8099 - Active (antagonists): 548 - Inactive: 6242 Data preprocessing: - Removed duplicate entries based on compound identifiers. - Resolved conflicting labels by excluding compounds with inconsistent activity annotations. Final cleaned dataset: - Total compounds: 6321 - Positive (antagonists): 416 - Negative (inactive): 5905